By Toshihisa Ishikawa, John Schuetz
ABC Transporters and Cancer presents worthy info at the fascinating and fast-moving box of melanoma study. right here, awesome and unique stories are offered on a number of themes. This quantity covers ABC transporters and melanoma, and is appropriate for researchers and scholars alike.
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Additional resources for ABC Transporters and Cancer
2014)CYT387JAK1/2––Durmus et al. (2013)DabrafenibBRAFOral uptake increased in absence of both transporters; individual contributions not determinedMittapalli et al. (2013)DasatinibBCR-ABL+–Lagas, van Waterschoot, et al. (2009) and Lagas, Vlaming, et al. (2009)ErlotinibEGFROral uptake increased in absence of both transporters; individual contributions not determinedMarchetti et al. (2008)GefitinibEGFR––Agarwal et al. (2011)ImatinibBCR-ABL––Oostendorp, Beijnen, et al. , (2009)N-desethyl sunitinibFGFR, PDGFR, and VEGFR––Tang, Lagas, et al.
The other concept of the BBB is that ABC transporter expression in this endothelial barrier is not static, but dynamic. , reactive oxygen species) that might be activated during the course of disease. Targeting these signaling events provides opportunities to rapidly and reversibly increase brain accumulation of drugs that are substrates for the transporters (potentially good). The clinical usefulness of targeting signaling to reduce efflux transporter activity and improve drug delivery to the CNS remains to be established.
2012). Table 2 In vivo impact of Abcb1a/1b and Abcg2 on the oral availability in mice of TKIs that are known to be transported by Abcb1 and/or Abcg2 Drug nameTarget molecule(s)Impact of Abcb1a/1bImpact of Abcg2ReferencesAxitinibVEGFR, c-KIT, and PDGFR–+Poller et al. (2011)CediranibVEGF––Wang et al. (2012)CrizotinibALK+–Tang et al. (2014)CYT387JAK1/2––Durmus et al. (2013)DabrafenibBRAFOral uptake increased in absence of both transporters; individual contributions not determinedMittapalli et al.
ABC Transporters and Cancer by Toshihisa Ishikawa, John Schuetz